Abstract | OBJECTIVE: The berries of blue honeysuckle (Lonicera caerulea L.), including an edible Kamchatka variety (var. kamtschatica Sevast.), are a potential but relatively unknown source of anthocyanins, which are thought to have favorable effects on diabetes and cardiovascular disease (CVD). The aim of this study was to examine whether the dietary addition of a Kamchatka honeysuckle berry extract (KHBE, 327 mg anthocyanins/g) is able to limit the disorders related to these diseases induced by a high- fructose diet in rats. METHODS: The experiment was conducted using 24 adult male Wistar rats distributed into 3 groups of 8 animals each and fed semipurified casein diets differentiated by the carbohydrate source for 4 wk, as follows: a control cornstarch diet (681 g/kg) or a high- fructose diet (633 g/kg), with or without the addition of KHBE (2 g/kg). RESULTS: CONCLUSION: An anthocyanin-rich Kamchatka honeysuckle berry extract supplemented to an unbalanced diet is able to ameliorate the disturbances in lipid and glucose metabolism that are the fundamental risk factors for CVD and diabetes. Moreover, the extract stimulates enzymatic activity within the gut that seems to be related to the metabolism of polyphenols.
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Authors | Adam Jurgoński, Jerzy Juśkiewicz, Zenon Zduńczyk |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 29
Issue 6
Pg. 898-902
(Jun 2013)
ISSN: 1873-1244 [Electronic] United States |
PMID | 23422536
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Anthocyanins
- Insulin
- Plant Extracts
- Triglycerides
- Fructose
- Lactase
- alpha-Glucosidases
- beta-Glucosidase
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Topics |
- Animals
- Anthocyanins
(chemistry, pharmacology)
- Carbohydrate Metabolism
(drug effects)
- Fructose
(administration & dosage)
- Fruit
(chemistry)
- Glucose Tolerance Test
- Hyperinsulinism
(drug therapy)
- Hyperlipidemias
(drug therapy)
- Insulin
(blood)
- Insulin Resistance
- Intestine, Small
(drug effects, metabolism, microbiology)
- Lactase
(metabolism)
- Lipid Metabolism
(drug effects)
- Lonicera
(chemistry)
- Male
- Plant Extracts
(chemistry, pharmacology)
- Rats
- Rats, Wistar
- Risk Factors
- Triglycerides
(blood)
- alpha-Glucosidases
(metabolism)
- beta-Glucosidase
(metabolism)
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