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Interference of colostral antibodies with response to a Bluetongue serotype 8 inactivated vaccine in lambs born from hyperimmune ewes.

Abstract
Despite the widespread use of Bluetongue serotype 8 (BTV-8) vaccines across Europe, there remain unanswered questions on the effects of maternally derived antibodies (MDA) on vaccination. This study investigated the persistence of MDA in lambs and their interference on vaccine efficacy. Lambs born from hyperimmune ewes-i.e. ewes naturally infected with BTV-8 in 2007 and repeatedly vaccinated thereafter-were used. They were allocated to five groups (n=7/group), four receiving a BTV-8 vaccine at different ages (3, 5, 7 and 9 months) and one left unvaccinated. Vaccine protection was assessed upon a BTV-8 challenge performed at 10 months of age. The neutralising antibody titres were also measured throughout the study. Vaccination at 5, 7 and 9 months led to seroconversion and full clinical and virological protection in all animals. Among lambs vaccinated at 3 months, three (3/7) did not respond to vaccination and were not protected from challenge infection. Others animals (4/7) were fully protected from clinical disease and viraemia in accordance with their seropositive status at time of challenge. In our very stringent conditions, MDA hampered response to BTV-8 vaccination in lambs for at least 3 months after birth. Accordingly, the optimal age of vaccination needs to be adjusted to the immune status of the sheep population.
AuthorsJérôme Leemans, Claude Hamers, Roland Chery, Amandine Bibard, Laure Besancon, Michelle Duboeuf, Pascal Hudelet, Sylvain Goutebroze, Nathalie Kirschvink
JournalVaccine (Vaccine) Vol. 31 Issue 15 Pg. 1975-80 (Apr 08 2013) ISSN: 1873-2518 [Electronic] Netherlands
PMID23422141 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • RNA, Viral
  • Vaccines, Inactivated
  • Viral Vaccines
Topics
  • Animals
  • Animals, Newborn (immunology)
  • Antibodies, Neutralizing (analysis, immunology)
  • Antibodies, Viral (analysis, immunology)
  • Bluetongue (immunology, prevention & control, virology)
  • Bluetongue virus (genetics, immunology, isolation & purification)
  • Colostrum (immunology)
  • Female
  • France
  • Pregnancy
  • RNA, Viral (analysis)
  • Sheep, Domestic (immunology, virology)
  • Time Factors
  • Vaccination (veterinary)
  • Vaccines, Inactivated (administration & dosage, immunology)
  • Viral Vaccines (administration & dosage, immunology)

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