Randomized controlled observer-blinded treatment of chronic foot eczema with iontophoresis and bath-PUVA.

Abstract	The aim of this study was to investigate the effect of iontophoresis combined with local psoralen plus ultraviolet A (PUVA) therapy in chronic foot eczema. A randomized, observer-blinded, multi-centre study was conducted in 48 patients with chronic moderate-to-severe foot eczema randomized to one of 3 groups: In the iontophoresis group local bath-PUVA was preceded by iontophoresis. In the PUVA group only local PUVA was given. The corticosteroid group was treated with fluticasone. All treatments were given for 8 weeks, with an 8-week follow-up period. The primary efficacy parameter was eczema score described by Rosén et al. Secondary efficacy parameters were a global impression by the patient, and the Dermatology Life Quality Index (DLQI). The eczema score and the DLQI decreased significantly over time. There were no significant differences in the decrease in eczema score (p=0.053) and DLQI values (p=0.563) between the 3 treatments. The DLQI values in our chronic foot eczema patients were high. There was no obvious advantage of local bath-PUVA with or with-out iontophoresis over local steroid therapy.
Authors	Ron A Tupker, Pieter J Coenraads, Pieter Zanen, Marie Louise A Schuttelaar
Journal	Acta dermato-venereologica (Acta Derm Venereol) Vol. 93 Issue 4 Pg. 456-60 (Jul 06 2013) ISSN: 1651-2057 [Electronic] Sweden
PMID	23420314 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References	Adrenal Cortex Hormones Androstadienes Photosensitizing Agents Fluticasone Ficusin
Topics	Administration, Cutaneous Adrenal Cortex Hormones (administration & dosage) Adult Androstadienes (administration & dosage) Combined Modality Therapy Eczema (diagnosis, psychology, therapy) Female Ficusin (administration & dosage) Fluticasone Foot Dermatoses (diagnosis, psychology, therapy) Humans Iontophoresis Male Middle Aged Netherlands PUVA Therapy Photosensitizing Agents (administration & dosage) Quality of Life Severity of Illness Index Surveys and Questionnaires Time Factors Treatment Outcome

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