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Acute anterior uveitis following intravitreal injection of bevacizumab.

AbstractBACKGROUND AND OBJECTIVE:
To report five cases of iritis after intravitreal injection of bevacizumab.
PATIENTS AND METHODS:
The clinical charts of patients who received intravitreal injections of bevacizumab or ranibizumab from January 2009 to September 2011 by one physician were retrospectively reviewed.
RESULTS:
A total of 1,097 injections of bevacizumab and 571 of ranibizumab were administered. Five patients developed acute anterior uveitis and presented with severe pain, photophobia, conjunctival injection, and anterior chamber reaction 2 to 24 hours after intravitreal injection of bevacizumab. All five patients were treated with topical corticosteroids with rapid resolution of the inflammation.
CONCLUSION:
Although uncommon, acute iritis is a complication of intravitreal injection of bevacizumab.
AuthorsArash Mozayan, Samer Farah
JournalOphthalmic surgery, lasers & imaging retina (Ophthalmic Surg Lasers Imaging Retina) 2013 Jan-Feb Vol. 44 Issue 1 Pg. 25-7 ISSN: 2325-8179 [Electronic] United States
PMID23418730 (Publication Type: Journal Article)
CopyrightCopyright 2013, SLACK Incorporated.
Chemical References
  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • Glucocorticoids
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Bevacizumab
  • Ranibizumab
Topics
  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Angiogenesis Inhibitors (adverse effects)
  • Antibodies, Monoclonal, Humanized (adverse effects, therapeutic use)
  • Bevacizumab
  • Conjunctivitis (chemically induced, diagnosis, drug therapy)
  • Eye Pain (chemically induced, diagnosis, drug therapy)
  • Female
  • Glucocorticoids (therapeutic use)
  • Humans
  • Incidence
  • Intravitreal Injections
  • Iritis (chemically induced, diagnosis, drug therapy)
  • Photophobia (chemically induced, diagnosis, drug therapy)
  • Ranibizumab
  • Retinal Diseases (drug therapy)
  • Retrospective Studies
  • Vascular Endothelial Growth Factor A (antagonists & inhibitors)
  • Visual Acuity

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