Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.

Abstract

A series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which compounds 1, 5, 6, 20, 27 and 34 exhibited significantly higher activity against TMV than commercial Ribavirin both in vitro and in vivo. Furthermore, these compounds have more simple structure than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.

• Authors: Meng Wu, Ziwen Wang, Chuisong Meng, Kailiang Wang, Yanna Hu, Lizhong Wang, Qingmin Wang
• Journal: PloS one (PLoS One) Vol. 8 Issue 2 Pg. e56475 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 23418574 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acrylates
• Antiviral Agents
• Caffeic Acids
• Cinnamates
• Coumaric Acids
• cinnamic acid
• Ribavirin
• ferulic acid
• Vanillic Acid
• acrylic acid
• caffeic acid

Topics

• Acrylates (chemistry, pharmacology)
• Antiviral Agents (chemistry, pharmacology)
• Caffeic Acids (chemistry, pharmacology)
• Cinnamates (chemistry, pharmacology)
• Coumaric Acids (chemistry, pharmacology)
• Drug Discovery
• Host-Pathogen Interactions (drug effects)
• Models, Chemical
• Molecular Structure
• Plant Leaves (virology)
• Ribavirin (chemistry, pharmacology)
• Structure-Activity Relationship
• Tobacco (virology)
• Tobacco Mosaic Virus (drug effects, physiology)
• Vanillic Acid (chemistry, pharmacology)