Abstract | OBJECTIVE: METHODS: Children receiving carvedilol for treatment of dilated cardiomyopathy with moderate to severe ventricular dysfunction were included into the study. Data on history, clinical examination and investigations were obtained and detailed echocardiography findings were recorded for the initial and all subsequent visits. RESULTS: Thirty-three children, mean age 26 ± 30 mo (range 7 mo to 138 mo) were enrolled. Carvedilol was initiated at a mean dose of 0.14 ± 0.03 mg/kg/d and the maintenance dose was 0.46 ± 0.14 mg/kg/d. At a follow up of 6-90 mo (mean of 28 ± 23 mo), functional class using Ross classification for pediatric heart failure improved from 2.7 to 1.3. The left ventricular ejection fraction rose from a basal value of 22 % ± 7 % (10-40 %) to 42 % ± 15 % (15-65 %) (p < 0.0001). Similarly, left ventricular fractional shortening increased significantly from 16 ± 6 % (8-34 %) to 21 ± 7 % (10-44 %) (p < 0.0001). One patient deteriorated and died of refractory heart failure. Carvedilol was discontinued in two more patients temporarily due to bronchospasm during respiratory infection. CONCLUSIONS:
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Authors | Anita Saxena, Om Murty Anil, Rajnish Juneja |
Journal | Indian journal of pediatrics
(Indian J Pediatr)
Vol. 80
Issue 7
Pg. 549-54
(Jul 2013)
ISSN: 0973-7693 [Electronic] India |
PMID | 23412984
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Carbazoles
- Propanolamines
- Carvedilol
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Topics |
- Adolescent
- Adrenergic beta-Antagonists
(therapeutic use)
- Carbazoles
(therapeutic use)
- Cardiomyopathy, Dilated
(diagnostic imaging, drug therapy, physiopathology)
- Carvedilol
- Child
- Child, Preschool
- Drug Therapy, Combination
- Echocardiography
- Female
- Humans
- Infant
- Male
- Propanolamines
(therapeutic use)
- Treatment Outcome
- Ventricular Dysfunction, Left
(diagnostic imaging, drug therapy, physiopathology)
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