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The risk of early cardiovascular disease in Lithuanian diabetic children and adolescents: a type 1 diabetes register database based study.

AbstractAIMS:
The aim was to assess the frequency and correlates of selected cardiovascular disease risk factors among Lithuanian children and adolescents with type 1 diabetes mellitus (T1DM).
METHODS:
A cohort of 539 T1DM children was investigated. Total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), glycated haemoglobin (HbA1c) was determined.
RESULTS:
The mean of HbA1c was 8.5 ± 1.8%. Overweight was present in 72 (13.4%, 95% CI 10.6-16.9) and 113 (21.0%, 95% CI 17.5-25.3) had arterial hypertension. Hypercholesterolemia was diagnosed in 120 (22.3%; 95% CI 18.6-26.7), decreased HDL in 22 (4.1%; 95% CI 2.7-6.2), high LDL in 79 (14.7%; 95% CI 11.8-18.3), and high TG in 96 (17.8%, 95% CI 14.7-21.9) subjects. There were positive linear correlations between TG and high HbA1c levels (r=0.192; p<0.001), and between LDL and high HbA1c levels (r=0.238; p<0.001). Two cardiovascular risk factors were present 14.3%, three risk factors in 6.9%, four in 2.4% and five in 0.9%. The frequency of two cardiovascular risk factors was higher among 10-17-year-old T1DM patients than among 1-9-year-old children (27.0% vs. 13.3% respectively, p<0.01).
CONCLUSION:
The frequency of cardiovascular risk factors is common in young people with T1DM and was associated with poor glycaemic control.
AuthorsRimantė Dobrovolskienė, Giedrė Mockevičienė, Bronislava Urbonaitė, Nijolė Jurgevičienė, Romualdas Tomas Preikša, Rytas Ostrauskas
JournalDiabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 100 Issue 1 Pg. 119-25 (Apr 2013) ISSN: 1872-8227 [Electronic] Ireland
PMID23410726 (Publication Type: Journal Article)
CopyrightCopyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Glycated Hemoglobin A
  • Triglycerides
  • hemoglobin A1c protein, human
Topics
  • Adolescent
  • Blood Glucose (metabolism)
  • Cardiovascular Diseases (blood, epidemiology, prevention & control)
  • Child
  • Child, Preschool
  • Cholesterol, HDL (blood)
  • Cholesterol, LDL (blood)
  • Cohort Studies
  • Diabetes Mellitus, Type 1 (blood, epidemiology, prevention & control)
  • Diabetic Angiopathies (blood, epidemiology, prevention & control)
  • Dyslipidemias (epidemiology)
  • Female
  • Glycated Hemoglobin (metabolism)
  • Humans
  • Hypercholesterolemia (epidemiology)
  • Infant
  • Lithuania (epidemiology)
  • Male
  • Overweight (blood)
  • Risk Factors
  • Triglycerides (blood)

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