Abstract |
Eosinophilic granuloma, a type of Langerhans cell histiocytosis, exhibits a classic vertebral collapse, which is called vertebra plana (Calve's disease) and it manifests as a solitary bony lesion. Vertebra plana can cause severe pain in patients. Bisphosphonates ( clodronate, pamidronate and zoledronic acid) have been recently used to treat osteolytic bone lesions of LCH. Zoledronic acid has 100 times relative potency that of pamidronate. We report a case of a 10-year-old girl who had zoledronic acid treatment for severe back pain due to vertebra plana. X-ray photographs of the patient's body showed dense metaphyseal band sign, which can be found in lead poisoning, treated leukemia, healing rickets, recovery from scurvy, vitamin D hypervitaminosis, congenital hypothyroidism and hypoparathyroidism. Increased biological potent zoledronic acid deprived her of severe back pain due to vertebra plana and might cause dense metaphyseal band sign of her skeleton. Conclusion; We have cured the severe back pain of a 10-year-old girl case of eosinophilic granuloma with zoledronic acid. After that treatment, X-ray photographs of the patient's body showed dense metaphyseal band sign. There have been few such cases reported until now.
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Authors | Ichiro Kikkawa, Toshinori Aihara, Akira Morimoto, Hideaki Watanabe, Rieko Furukawa |
Journal | Pediatrics international : official journal of the Japan Pediatric Society
(Pediatr Int)
Vol. 55
Issue 1
Pg. 96-8
(Feb 2013)
ISSN: 1442-200X [Electronic] Australia |
PMID | 23409985
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society. |
Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
- Imidazoles
- Zoledronic Acid
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Topics |
- Bone Density Conservation Agents
(adverse effects, therapeutic use)
- Child
- Diphosphonates
(adverse effects, therapeutic use)
- Female
- Histiocytosis, Langerhans-Cell
(complications)
- Humans
- Imidazoles
(adverse effects, therapeutic use)
- Knee Joint
(diagnostic imaging, drug effects)
- Radiography
- Spinal Diseases
(diagnostic imaging, drug therapy, etiology)
- Thoracic Vertebrae
(diagnostic imaging)
- Zoledronic Acid
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