Abstract | BACKGROUND: Acinar cell neoplasms of the pancreas are rare but when encountered, the diagnosis is often established based on cytology specimens. Diagnostic accuracy is important because acinar cell carcinomas are aggressive yet may mimic tumors with different outcomes and management. METHODS: The authors identified all patients with a diagnosis of acinar cell neoplasm in the institutional database; assessed cytomorphology and immunocytochemistry for trypsin, chymotrypsin, synaptophysin, chromogranin A, and MIB-1; and compared all cytology and final histological diagnoses for diagnostic discrepancies. RESULTS: CONCLUSIONS:
Acinar cell carcinoma has a distinctive cytological appearance but is frequently misdiagnosed on cytology. Immunocytochemistry is useful for identifying acinar differentiation.
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Authors | Carlie S Sigel, David S Klimstra |
Journal | Cancer cytopathology
(Cancer Cytopathol)
Vol. 121
Issue 8
Pg. 459-70
(Aug 2013)
ISSN: 1934-6638 [Electronic] United States |
PMID | 23408736
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 American Cancer Society. |
Topics |
- Adult
- Carcinoma, Acinar Cell
(metabolism, pathology)
- Child
- Female
- Humans
- Immunohistochemistry
- Immunophenotyping
- Male
- Middle Aged
- Pancreatic Neoplasms
(metabolism, pathology)
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