Abstract | BACKGROUND: MATERIALS AND METHODS: Overall, 268 Japanese individuals who visited a clinic located in an urban area for H. pylori infection tests and subsequent eradication were enrolled. H. pylori infection was diagnosed by a (13) C- urea breath test, with positive results defined as values ≥2.5‰. RESULTS: The overall infection rate was 65.3% (175/268). The geometric mean serum iron levels in uninfected and infected subjects were 115.7 μg/dL and 108.9 μg/dL, respectively, in men, and 83.9 and 91.8 μg/dL, respectively, in women. The geometric mean serum ferritin levels were 128.9 and 81.0 ng/mL, respectively, in men, and 25.5 and 27.0 ng/mL, respectively, in women. Regression analysis adjusted for age showed that lower geometric mean serum ferritin levels were significantly associated with H. pylori infection in men (131.8 vs 79.4 ng/mL p = .009) and in women (33.9 vs 23.4 ng/mL p = .041). The difference was greater in subjects ≥50 years old, although the interaction was not statistically significant. Helicobacter pylori infection was not significantly associated with serum iron levels. CONCLUSION: This study showed that H. pylori infection was significantly associated with altered serum ferritin levels in Japanese individuals, particularly in those aged ≥50 years.
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Authors | Hiroko Nakagawa, Takashi Tamura, Yoko Mitsuda, Mio Kurata, Yasuyuki Goto, Yoshikazu Kamiya, Takaaki Kondo, Nobuyuki Hamajima |
Journal | Helicobacter
(Helicobacter)
Vol. 18
Issue 4
Pg. 309-15
(Aug 2013)
ISSN: 1523-5378 [Electronic] England |
PMID | 23406272
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 John Wiley & Sons Ltd. |
Chemical References |
- Biomarkers
- Urea
- Ferritins
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Topics |
- Adult
- Aged
- Asian People
- Biomarkers
(blood)
- Breath Tests
- Female
- Ferritins
(blood)
- Helicobacter Infections
(diagnosis, pathology)
- Humans
- Japan
- Male
- Middle Aged
- Serum
(chemistry)
- Urea
(analysis)
- Young Adult
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