Screening test for malignant hyperthermia in patients with persistent hyperCKemia: a pilot study.

Abstract

INTRODUCTION:

Persistently elevated serum creatine kinase (CK) is frequently associated with predisposition to malignant hyperthermia (MH). We investigated whether a minimally invasive metabolic test is suitable to diagnose MH susceptibility among patients with hyperCKemia.

METHODS:

Thirty-nine participants were included: 10 were MH susceptible (MHS); 21 MH were non-susceptible (MHN); and 8 had MHN with persistent hyperCKemia >500 U/L. Microdialysis probes were inserted into the vastus lateralis muscle, and halothane or caffeine was injected via an attached microtubing catheter. Lactate concentrations in dialysis samples were measured spectrophotometrically.

RESULTS:

Baseline lactate did not differ between the groups. After local application of halothane or caffeine, a significant lactate increase was detected only in the MHS group.

CONCLUSIONS:

Test results were not influenced by hyperCKemia. To avoid risks and complications of a surgical muscle biopsy this microdialysis test might be a useful screening tool for MH susceptibility among patients with persistent CK elevation.

• Authors: Stephan Johannsen, Christina Berberich, Thomas Metterlein, Cosima Roth, Karlheinz Reiners, Norbert Roewer, Frank Schuster
• Journal: Muscle & nerve (Muscle Nerve) Vol. 47 Issue 5 Pg. 677-81 (May 2013) ISSN: 1097-4598 [Electronic] United States
• PMID: 23400941 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Wiley Periodicals, Inc.

Chemical References

• Lactic Acid
• Creatine Kinase

Topics

• Adult
• Creatine Kinase (blood)
• Disease Susceptibility
• Female
• Humans
• Lactic Acid (metabolism)
• Male
• Malignant Hyperthermia (complications, diagnosis, metabolism)
• Microdialysis
• Middle Aged
• Muscle, Skeletal (metabolism)