Abstract | INTRODUCTION: Persistently elevated serum creatine kinase (CK) is frequently associated with predisposition to malignant hyperthermia (MH). We investigated whether a minimally invasive metabolic test is suitable to diagnose MH susceptibility among patients with hyperCKemia. METHODS: Thirty-nine participants were included: 10 were MH susceptible (MHS); 21 MH were non-susceptible (MHN); and 8 had MHN with persistent hyperCKemia >500 U/L. Microdialysis probes were inserted into the vastus lateralis muscle, and halothane or caffeine was injected via an attached microtubing catheter. Lactate concentrations in dialysis samples were measured spectrophotometrically. RESULTS: Baseline lactate did not differ between the groups. After local application of halothane or caffeine, a significant lactate increase was detected only in the MHS group. CONCLUSIONS: Test results were not influenced by hyperCKemia. To avoid risks and complications of a surgical muscle biopsy this microdialysis test might be a useful screening tool for MH susceptibility among patients with persistent CK elevation.
|
Authors | Stephan Johannsen, Christina Berberich, Thomas Metterlein, Cosima Roth, Karlheinz Reiners, Norbert Roewer, Frank Schuster |
Journal | Muscle & nerve
(Muscle Nerve)
Vol. 47
Issue 5
Pg. 677-81
(May 2013)
ISSN: 1097-4598 [Electronic] United States |
PMID | 23400941
(Publication Type: Journal Article)
|
Copyright | Copyright © 2012 Wiley Periodicals, Inc. |
Chemical References |
- Lactic Acid
- Creatine Kinase
|
Topics |
- Adult
- Creatine Kinase
(blood)
- Disease Susceptibility
- Female
- Humans
- Lactic Acid
(metabolism)
- Male
- Malignant Hyperthermia
(complications, diagnosis, metabolism)
- Microdialysis
- Middle Aged
- Muscle, Skeletal
(metabolism)
|