Abstract |
Deep Brain Stimulation (DBS) is a successful novel treatment for treatment-resistant obsessive-compulsive disorder and is currently under investigation for addiction and eating disorders. Clinical and preclinical studies have shown functional changes in the orbitofrontal cortex (OFC) following DBS in the ventral capsule/ventral striatum. These findings suggest that DBS can affect neural activity in distant regions that are connected to the site of electrode implantation. However, the behavioral consequences of direct OFC stimulation are not known. Here, we studied the effects of direct stimulation in the lateral OFC on spatial discrimination and reversal learning in rats. Rats were implanted with stimulating electrodes and were trained on a spatial discrimination and reversal learning task. DBS in the OFC did not affect acquisition of a spatial discrimination. Stimulated animals made more incorrect responses during the first reversal. Acquisition of the second reversal was not affected. These results suggest that DBS may inhibit activity in the OFC, or may disrupt output of the OFC to other cortical or subcortical areas, resulting in perseverative behavior or an inability to adapt behavior to altered response-reward contingencies.
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Authors | Marianne Klanker, Ger Post, Ruud Joosten, Matthijs Feenstra, Damiaan Denys |
Journal | Behavioural brain research
(Behav Brain Res)
Vol. 245
Pg. 7-12
(May 15 2013)
ISSN: 1872-7549 [Electronic] Netherlands |
PMID | 23396148
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier B.V. All rights reserved. |
Topics |
- Animals
- Conditioning, Operant
(physiology)
- Data Interpretation, Statistical
- Deep Brain Stimulation
(adverse effects)
- Discrimination Learning
(physiology)
- Discrimination, Psychological
(physiology)
- Electrodes, Implanted
- Frontal Lobe
(physiology)
- Male
- Prefrontal Cortex
(physiology)
- Rats
- Rats, Wistar
- Reversal Learning
(physiology)
- Space Perception
(physiology)
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