Systemic retinoids in the management of ichthyoses and related skin types.

Abstract

The term retinoid includes both natural and synthetic derivatives of vitamin A. Retinoid-containing treatments have been used since ~1550BC by the early Egyptians. Treatment of ichthyosiform disorders with retinoids dates back at least to the 1930s. Early use of high-dose vitamin A demonstrated efficacy, but because vitamin A is stored in the liver, toxicity limited usefulness. Interest turned to synthetic retinoids in an effort to enhance efficacy and limit toxicity. Acetretin, isotretinoin and, in the past etretinate, have provided the most effective therapy for ichthyosiform conditions. They have been used for a variety of ages, including in newborns with severe ichthyosis and for decades in some patients. Careful surveillance and management of mucous membrane, laboratory, skeletal, and teratogenic side effects has made systemic retinoids the mainstay of therapy for ichthyosis and related skin types.

• Authors: John J Digiovanna, Theodora Mauro, Leonard M Milstone, Matthias Schmuth, Jorge R Toro
• Journal: Dermatologic therapy (Dermatol Ther) 2013 Jan-Feb Vol. 26 Issue 1 Pg. 26-38 ISSN: 1529-8019 [Electronic] United States
• PMID: 23384018 (Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 Wiley Periodicals, Inc.

Chemical References

• Dermatologic Agents
• Retinoids
• Etretinate
• Isotretinoin
• Acitretin

Topics

• Acitretin (administration & dosage, adverse effects)
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Child
• Child, Preschool
• Dermatologic Agents (administration & dosage, adverse effects)
• Etretinate (administration & dosage, adverse effects)
• Humans
• Ichthyosis (drug therapy, pathology)
• Infant
• Infant, Newborn
• Isotretinoin (administration & dosage, adverse effects)
• Liver (drug effects)
• Middle Aged
• Patient Compliance (psychology)
• Patient Education as Topic
• Retinoids (administration & dosage, adverse effects)
• Risk Factors
• Skin Diseases, Genetic (drug therapy, pathology)
• Young Adult