Abstract | INTRODUCTION: One main complication of a flow-diverting device (FD) in treating intracranial aneurysm is stenosis of parent artery (PA) or occlusion of side branches. The use of a biodegradable device may satisfy the need for aneurysm occlusion and eliminate potential complications. METHODS: Twenty elastase-induced aneurysm rabbit models were divided into three groups: in group 1 (n = 7), polyglycolic acid FDs ( PGA-FDs) were implanted across the necks of aneurysms and the abdominal aortas (AA), covering the ostium of a lumbar artery; in group 2 (n = 7), the PGA-FDs were replaced by metal FDs; and in group 3 (n = 6), the PGA-FDs were only implanted across the necks of aneurysms. Animals in group 3 underwent angiography at 6 weeks; those in groups 1 and 2 underwent angiography at 3 months. The status of aneurysm embolization and patency of side branches were assessed. RESULTS: Complete aneurysm occlusion rates in groups 1 and 3 were 83.3 and 66.7 %, respectively, compared with 0 % in group 2. No side branch occlusions were noted. PA neointimal hyperplasia was minimal, and there were no significant differences between groups 1 and 2 (P = 0.233). The neointimal coverage ratio of the branch ostium in AA in group 1 was not significantly different from that in group 2 (P = 0.605). The neointima comprised predominantly smooth muscle cells and collagen fibers. CONCLUSIONS: The PGA-FD was an effective device for the treatment of aneurysms and was safe for side branches at the 3-month follow-up.
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Authors | Kuizhong Wang, Shaoji Yuan, Xuping Zhang, Qiang Liu, Qisheng Zhong, Rongwei Zhang, Peigang Lu, Jiwen Li |
Journal | Neuroradiology
(Neuroradiology)
Vol. 55
Issue 5
Pg. 621-8
(May 2013)
ISSN: 1432-1920 [Electronic] Germany |
PMID | 23381018
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Absorbable Implants
- Animals
- Blood Vessel Prosthesis
- Embolization, Therapeutic
(instrumentation)
- Equipment Failure Analysis
- Female
- Intracranial Aneurysm
(diagnostic imaging, surgery)
- Male
- Prosthesis Design
- Rabbits
- Radiography
- Stents
- Treatment Outcome
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