Antiproteinuric effect of angiotensin receptor blockers in normotensive patients with proteinuria: a meta-analysis of randomized controlled trials.

Abstract

INTRODUCTION:

The objective of this article is to evaluate the antiproteinuric effect of angiotensin receptor blockers (ARBs) in normotensive patients with proteinuria.

MATERIALS AND METHODS:

We reviewed randomized controlled trials assessing ARBs treatment in patients with normotension and proteinuria. Data concerning the study design, patient characteristics, and outcomes were extracted. Ratio of means was calculated by using the generalized inverse variance method.

RESULTS:

Eight trials involving 866 patients were included in this study. Compared with a control group, ARBs group was associated with a significant reduction in urinary protein excretion (ratio of means 0.53, 95% CI 0.44-0.64). Subgroup analysis shows that ARBs therapy resulted in a significant decrease in urinary protein excretion in diabetic patients with microalbuminuria or nondiabetic nephropathy with overt proteinuria (ratio of means 0.57, 95% CI 0.47-0.69 and 0.46, 95% CI 0.26-0.83, respectively), in a Western population or an Asian population (ratio of means 0.61, 95% CI 0.54-0.69 and 0.49, 95% CI 0.37-0.64, respectively), and in patients followed up for one to three months or three to 12 months (ratio of means 0.62, 95% CI 0.54-0.70 and 0.49, 95% CI 0.38-0.63, respectively).

CONCLUSIONS:

The data suggest that ARBs may have beneficial effects in preventing the progression of proteinuria in normotensive patients with renal disease.

• Authors: Deng-feng Geng, Wei-feng Sun, Li Yang, Ge En, Jing-feng Wang
• Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS (J Renin Angiotensin Aldosterone Syst) Vol. 15 Issue 1 Pg. 44-51 (Mar 2014) ISSN: 1752-8976 [Electronic] England
• PMID: 23378528 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Angiotensin II Type 1 Receptor Blockers
• Creatinine

Topics

• Adult
• Angiotensin II Type 1 Receptor Blockers (therapeutic use)
• Creatinine (blood, metabolism)
• Diabetic Nephropathies (drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Proteinuria (drug therapy)
• Randomized Controlled Trials as Topic