Abstract | OBJECTIVE:
Colon cancer is a common malignant neoplasm causing huge morbidity and mortality worldwide. Current therapeutic interventions are unsatisfying, which necessitates novel chemopreventive strategies. The present study was intended to elucidate the chemopreventive efficacy of hesperidin against azoxymethane (AOM)-induced mouse colon carcinogenesis. MATERIALS AND METHODS: RESULTS:
Hesperidin treatments significantly inhibited the number and multiplicities of AOM-induced ACF and tumor incidence. Hesperidin reduced oxidative stress parameters and enhanced antioxidant status. A marked decrease in the PCNA index was evident on hesperidin administration. Hesperidin treatments caused a prominent downregulation of NF-κB and its target molecules iNOS and COX-2, thereby combating inflammation. CONCLUSION: This study proves the chemopreventive efficacy of hesperidin against the deleterious traits of colon carcinogenesis including accelerated proliferation, inflammation and persistent oxidative stress.
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Authors | Gowrikumar Saiprasad, Palanivel Chitra, Ramar Manikandan, Ganapasam Sudhandiran |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 62
Issue 4
Pg. 425-40
(Apr 2013)
ISSN: 1420-908X [Electronic] Switzerland |
PMID | 23377175
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Antineoplastic Agents
- Biomarkers
- Carcinogens
- NF-kappa B
- Proliferating Cell Nuclear Antigen
- Hesperidin
- Nitric Oxide Synthase Type II
- Nos2 protein, mouse
- Ptgs2 protein, mouse
- Cyclooxygenase 2
- Azoxymethane
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology, therapeutic use)
- Antineoplastic Agents
(pharmacology, therapeutic use)
- Azoxymethane
- Biomarkers
(metabolism)
- Carcinogens
- Cell Proliferation
(drug effects)
- Colonic Neoplasms
(chemically induced, drug therapy, metabolism, pathology)
- Cyclooxygenase 2
(metabolism)
- Down-Regulation
- Hesperidin
(pharmacology, therapeutic use)
- Inflammation
(drug therapy, metabolism, pathology)
- Male
- Mice
- NF-kappa B
(metabolism)
- Nitric Oxide Synthase Type II
(metabolism)
- Oxidative Stress
(drug effects)
- Proliferating Cell Nuclear Antigen
(metabolism)
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