[The lipid metabolism abnormality in patients administered with olanzapine].

Abstract

The atypical antipsychotic medication olanzapine is a useful agent in acute and maintenance treatment of schizophrenia and related disorders. It has beneficial effects on both positive and negative symptoms, an early onset of antipsychotic action and a favourable side effect profile. On the other hand, olanzapine has many reports of causing weight gain, glucose metabolism disturbances and lipidosis. We carried out blood tests (leptin, adiponectin, remnant-like lipoprotein cholesterol (RLP-C), total cholesterol, HbA1C, 75-OGTT and etc.) on patients with schizophrenia who had taken olanzapine. As a result, leptin, neutral lipid and RLP-C were significantly correlated by BMI. (The average blood test data and BMI revealed a normal range). Most analysis results of the lipoprotein fraction by a polyacrylamide-gel-electrophoresis method were normal patterns. Furthermore, the serum insulin concentrations from 75 g glucose tolerance (75 g-OGTT) 30 minutes later, in one third of patients receiving olanzapine, registered more than 100 microU/ml. The mechanism of the insulin secretion rise by olannzapine is unknown. Olanzapine may impair glucose tolerance due in part to increased insulin resistance. These findings do not necessarily imply that olanzapine is directly associated with a risk of impairment of weight gain, glucose metabolism disturbances and lipidosis. These results suggest that it is useful to promote diet cure and exercise therapy with patients with high BMI levels.

• Authors: Taku Amano, Shigetoshi Hosaka, Hiroshi Takami, Chie Sugiyama, Kazue Oda, Ryuichi Morikawa
• Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology (Nihon Shinkei Seishin Yakurigaku Zasshi) Vol. 32 Issue 5-6 Pg. 257-61 (Nov 2012) ISSN: 1340-2544 [Print] Japan
• PMID: 23373312 (Publication Type: Journal Article)

Chemical References

• Antipsychotic Agents
• Blood Glucose
• Insulin
• Benzodiazepines
• Olanzapine

Topics

• Adult
• Antipsychotic Agents (therapeutic use)
• Benzodiazepines (therapeutic use)
• Blood Glucose (physiology)
• Body Mass Index
• Female
• Humans
• Insulin (blood)
• Lipid Metabolism (drug effects)
• Male
• Middle Aged
• Olanzapine
• Schizophrenia (drug therapy, metabolism)
• Weight Gain