Abstract | BACKGROUND: OBJECTIVE: METHODS:
Ethanol-free morphine 2 mg/mL oral solution was diluted to 0.4 mg/mL with sterile water and stored in a light protected container at room temperature (20°C-25°C). The change in morphine concentration over time was measured by liquid chromatography mass spectrometry with simultaneous ultraviolet diode array detection. RESULTS: : The test morphine solution retained 107% of its original concentration after 60 days. CONCLUSION: Extemporaneously prepared 0.4 mg/mL oral morphine solution is suitable for use in the treatment of NAS as a potentially safer alternative to opium-containing agents.
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Authors | Jason Sauberan, Steven Rossi, Jae H Kim |
Journal | Journal of addiction medicine
(J Addict Med)
2013 Mar-Apr
Vol. 7
Issue 2
Pg. 113-5
ISSN: 1932-0620 [Print] United States |
PMID | 23370932
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Narcotics
- Pharmaceutical Solutions
- Morphine
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Topics |
- Administration, Oral
- Chromatography, High Pressure Liquid
(methods)
- Drug Compounding
(methods)
- Drug Stability
- Drug Storage
- Humans
- Infant, Newborn
- Morphine
(chemistry)
- Narcotics
(chemistry)
- Neonatal Abstinence Syndrome
- Pharmaceutical Solutions
- United States
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