Cerebrospinal fluid (1,3)-β-D-glucan detection as an aid for diagnosis of iatrogenic fungal meningitis.

Abstract

This case series highlights our experience with use of the Fungitell assay for quantifying (1,3)-β-d-glucan in cerebrospinal fluid during the current U.S. outbreak of fungal meningitis related to contaminated methylprednisolone acetate. This test may prove a useful adjunct in diagnosis and management of exposed patients.

• Authors: Jennifer L Lyons, Karen L Roos, Kieren A Marr, Henry Neumann, Julie B Trivedi, Dorlan J Kimbrough, Lisa Steiner, Kiran T Thakur, Daniel M Harrison, Sean X Zhang
• Journal: Journal of clinical microbiology (J Clin Microbiol) Vol. 51 Issue 4 Pg. 1285-7 (Apr 2013) ISSN: 1098-660X [Electronic] United States
• PMID: 23363831 (Publication Type: Case Reports, Evaluation Study, Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Proteoglycans
• beta-Glucans
• polysaccharide-K
• Methylprednisolone Acetate
• Methylprednisolone

Topics

• Adult
• Aged
• Cerebrospinal Fluid (chemistry)
• Drug Contamination
• Female
• Humans
• Iatrogenic Disease
• Male
• Meningitis, Fungal (diagnosis)
• Methylprednisolone (administration & dosage, adverse effects, analogs & derivatives)
• Methylprednisolone Acetate
• Middle Aged
• Proteoglycans
• beta-Glucans (cerebrospinal fluid)