Abstract |
Enteropathy-associated T-cell lymphoma (EATL) is a rare subtype of peripheral T-cell lymphomas with a poor prognosis. Autologous stem cell transplantation (ASCT) was retrospectively evaluated as a consolidation or salvage strategy for EATL. The analysis included 44 patients who received ASCT for EATL between 2000 and 2010. Thirty-one patients (70%) were in first complete or partial remission at the time of the ASCT. With a median follow-up of 46 months, relapse incidence, progression-free survival, and overall survival were 39%, 54%, and 59% at 4 years, respectively, with only one relapse occurring beyond 18 months posttransplant. There was a trend for better survival in patients transplanted in first complete or partial remission at 4 years (66% vs 36%; P = .062). ASCT is feasible in selected patients with EATL and can yield durable disease control in a significant proportion of the patients.
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Authors | Esa Jantunen, Ariane Boumendil, Herve Finel, Jian-Jian Luan, Peter Johnson, Alessandro Rambaldi, Andrew Haynes, Michel A Duchosal, Wolfgang Bethge, Pierre Biron, Kristina Carlson, Charles Craddock, Claudius Rudin, Jurgen Finke, Gilles Salles, Frank Kroschinsky, Anna Sureda, Peter Dreger, Lymphoma Working Party of the EBMT |
Journal | Blood
(Blood)
Vol. 121
Issue 13
Pg. 2529-32
(Mar 28 2013)
ISSN: 1528-0020 [Electronic] United States |
PMID | 23361910
(Publication Type: Evaluation Study, Journal Article)
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Topics |
- Adult
- Aged
- Enteropathy-Associated T-Cell Lymphoma
(diagnosis, mortality, therapy)
- Female
- Germany
(epidemiology)
- Hematopoietic Stem Cell Transplantation
(methods)
- Humans
- Male
- Medical Oncology
(organization & administration)
- Middle Aged
- Retrospective Studies
- Societies, Medical
- Survival Analysis
- Transplantation, Autologous
- Treatment Outcome
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