Abstract | OBJECTIVE: MATERIALS AND METHODS: This retrospective study included 46 formalin-fixed, paraffin-embedded blocks of mucoepidermoid carcinoma. Based on histopathologic parameters, samples were classified into three grades. Then new sections were made and stained by immunohistochemistry (IHC) method for EGFR and c-erbB-2. Finally, EGFR and c-erbB-2 expression and their correlation with histopathologic grading were statistically analyzed by ANOVA. Nineteen samples of normal salivary gland tissue were also chosen as control group. RESULTS: The means of EGFR and c-erbB-2 were 71%, 71%, respectively. Statistically significant correlation was found between EGFR expression and histopathologic grading of mucoepidermoid carcinoma of salivary glands (P < 0.001). There was no statistically significant correlation between histopathologic grading of salivary gland mucoepidermoid carcinoma and c-erbB-2 expression (P = 0.60). CONCLUSION: There is a parallelism between an increase in EGFR expression and increase in the histopathologic grading of salivary gland mucoepidermoid carcinoma. Therefore, the biologic behavior of salivary gland mucoepidermoid carcinoma can be determined by EGFR expression and it is a useful technique for determination of tumor grades and probably their prognosis.
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Authors | Monir Moradzadeh Khiavi, Sepideh Vosoughhosseini, Shirin Saravani, Monireh Halimi |
Journal | Journal of cancer research and therapeutics
(J Cancer Res Ther)
2012 Oct-Dec
Vol. 8
Issue 4
Pg. 586-90
ISSN: 1998-4138 [Electronic] India |
PMID | 23361279
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ErbB Receptors
- Receptor, ErbB-2
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Mucoepidermoid
(metabolism, pathology)
- Child
- ErbB Receptors
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Neoplasm Grading
- Receptor, ErbB-2
(metabolism)
- Salivary Gland Neoplasms
(metabolism, pathology)
- Young Adult
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