Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats.

Abstract	Saturated and trans fatty acids have been associated with the risk to develop cardiovascular diseases. However, health-promoting effects are associated with consumption of anhydrous milk fat (AMF) and ruminant trans fatty acids, such as conjugated linoleic acid (CLA) and vaccenic acid (VA) contained in the lipid fraction of milk and dairy products. The purpose of this study was to evaluate the effect of AMF naturally enriched with CLA and VA in spontaneously hypertensive rats (SHR), using sterculic oil to inhibit the conversion of VA into CLA. The administration of AMF to SHR during 7 weeks exerted beneficial effects on cardiovascular risk biomarkers (reduction of insulin, blood lipids, increase of adiponectin). When sterculic oil was included, some parameters were further ameliorated (reduction of insulin, increase of adiponectin). Sterculic oil alone reduced body weight and adiposity, and improved blood pressure, adiponectin and triglyceride levels.
Authors	M S Herrera-Meza, M R Mendoza-López, O García-Barradas, M G Sanchez-Otero, E R Silva-Hernández, J O Angulo, R M Oliart-Ros
Journal	International journal of food sciences and nutrition (Int J Food Sci Nutr) Vol. 64 Issue 5 Pg. 575-86 (Aug 2013) ISSN: 1465-3478 [Electronic] England
PMID	23360131 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adiponectin Biomarkers Cyclopropanes Dietary Fats Fatty Acids, Monounsaturated Insulin Linoleic Acids, Conjugated Lipids Oleic Acids Triglycerides Linoleic Acid 11-octadecenoic acid sterculic acid
Topics	Adiponectin (blood) Adiposity (drug effects) Animals Biomarkers (blood) Blood Pressure (drug effects) Cardiovascular Diseases (blood, etiology, prevention & control) Cyclopropanes (pharmacology, therapeutic use) Diet Dietary Fats (pharmacology, therapeutic use) Fatty Acids, Monounsaturated (pharmacology, therapeutic use) Hypertension (blood, drug therapy) Insulin (blood) Linoleic Acid (pharmacology, therapeutic use) Linoleic Acids, Conjugated (pharmacology, therapeutic use) Lipids (blood) Male Milk (chemistry) Oleic Acids (pharmacology, therapeutic use) Rats Rats, Inbred SHR Ruminants Triglycerides (blood) Weight Loss (drug effects)

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