Clinical factors predicting for prolonged enteral supplementation in patients with oropharyngeal cancer treated with chemoradiation.

Abstract

OBJECTIVES:

The purpose of this study is to determine the pre-treatment clinical factors associated with prolonged enteral feeding in patients with oropharyngeal cancer treated with chemoradiation.

MATERIALS AND METHODS:

One hundred and nine patients with stage III-IVB oropharyngeal carcinoma treated with definitive chemoradiation were analyzed. Feeding tube usage was defined as the duration of active usage for nutritional purposes.

RESULTS:

Median follow-up was 4.4 years and median feeding tube usage was 2.5 months. On multivariate analysis, increasing duration of feeding tube usage was associated with narcotic use before treatment (p = 0.04), living alone at the time of treatment (p = 0.04), and larger pre-treatment decrease in body-mass index (p = 0.01). Prolonged feeding tube usage was associated with decreased overall survival (p = 0.06) and disease-free survival (p = 0.02) in univariate analysis.

CONCLUSIONS:

By identifying patients at risk for prolonged feeding tube usage, aggressive measures can be attempted to prevent feeding tube dependence.

• Authors: Joanne W Jang, Ron J Parambi, Sean M McBride, Tessa A Goldsmith, Allison S Holman, Annie W Chan
• Journal: Oral oncology (Oral Oncol) Vol. 49 Issue 5 Pg. 438-42 (May 2013) ISSN: 1879-0593 [Electronic] England
• PMID: 23357527 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Narcotics

Topics

• Adult
• Aged
• Aged, 80 and over
• Body Mass Index
• Chemoradiotherapy
• Chemotherapy, Adjuvant
• Cohort Studies
• Disease-Free Survival
• Enteral Nutrition (statistics & numerical data)
• Female
• Follow-Up Studies
• Forecasting
• Gastrostomy (instrumentation)
• Humans
• Induction Chemotherapy
• Male
• Middle Aged
• Narcotics (therapeutic use)
• Neck Dissection
• Neoplasm Staging
• Nutritional Support
• Oropharyngeal Neoplasms (therapy)
• Radiotherapy Dosage
• Radiotherapy, Intensity-Modulated
• Residence Characteristics
• Survival Rate
• Time Factors
• Treatment Outcome
• Weight Loss