Abstract | BACKGROUND: The likelihood of cesarean is in part related to maternal body mass index (BMI). Myometrial changes may be responsible. METHODS: Myometrial biopsies were collected from the upper edge of the hysterotomy from women undergoing scheduled cesarean with term, singleton gestations. Oxytocin receptor and connexin-43 mRNA protein expression was quantified with real-time polymerase chain reaction and Western blot. RESULTS: Twenty subjects were recruited: 13 repeat and 7 primary cesareans. Oxytocin receptor mRNA was associated with BMI among women undergoing primary (r = 0.75; p = 0.05) but not repeat cesarean (p > 0.05). Controlling for gestational age, this association strengthened (p = 0.004). Receptor protein expression showed a linear correlation with BMI in the primary cesarean group (p = 0.002). Connexin-43 mRNA expression was not related to BMI in women undergoing primary (r = -0.14, p = 0.76) or repeat (r = -0.01, p = 0.86) cesarean. CONCLUSIONS:
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Authors | Matthew J Garabedian, Wendy F Hansen, Lauren A McCord, Mark A Manning, John M O'Brien, Thomas E Curry Jr |
Journal | American journal of perinatology
(Am J Perinatol)
Vol. 30
Issue 6
Pg. 491-7
(Jun 2013)
ISSN: 1098-8785 [Electronic] United States |
PMID | 23355275
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. |
Chemical References |
- Connexin 43
- RNA, Messenger
- Receptors, Oxytocin
- Inhibin-beta Subunits
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Topics |
- Adult
- Blotting, Western
- Body Mass Index
- Cesarean Section
- Connexin 43
(metabolism)
- Female
- Humans
- Inhibin-beta Subunits
(metabolism)
- Myometrium
(metabolism)
- Pregnancy
- RNA, Messenger
(metabolism)
- Receptors, Oxytocin
(metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Up-Regulation
(physiology)
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