Napsin A expression in primary mucin-producing adenocarcinomas of the lung: an immunohistochemical study.

Abstract

Immunohistochemical expression of napsin A in primary pulmonary mucinous tumors is not well established. Napsin A immunoreactivity was evaluated in 43 mucin-producing adenocarcinomas of the lung consisting of 18 tumors formerly classified as mucinous bronchioloalveolar carcinoma, 15 colloid adenocarcinomas, 5 solid predominant adenocarcinomas with mucin production, and 5 adenocarcinomas with signet ring cell features, as well as in 25 extrapulmonary mucinous adenocarcinomas of different anatomic sites. Immunohistochemical expression of thyroid transcription factor 1 (TTF-1) was also compared. Thirty-three percent of mucinous lung tumors exhibited positive immunoreactivity for napsin A, whereas 42% expressed TTF-1. All 25 extrapulmonary mucinous adenocarcinomas lacked expression of napsin A and TTF-1. Mucin-producing neoplasms of the lung infrequently express napsin A, suggesting that immunohistochemical assessment of napsin A may have limited diagnostic usefulness for distinguishing primary and metastatic mucinous adenocarcinomas involving the lung.

• Authors: Jeffrey Wu, Peiguo G Chu, Zhong Jiang, Sean K Lau
• Journal: American journal of clinical pathology (Am J Clin Pathol) Vol. 139 Issue 2 Pg. 160-6 (Feb 2013) ISSN: 1943-7722 [Electronic] England
• PMID: 23355200 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• DNA-Binding Proteins
• TTF1 protein, human
• Transcription Factors
• Aspartic Acid Endopeptidases
• NAPSA protein, human

Topics

• Adenocarcinoma (metabolism, pathology, surgery)
• Aspartic Acid Endopeptidases (metabolism)
• Biomarkers, Tumor (metabolism)
• DNA-Binding Proteins (metabolism)
• Female
• Humans
• Immunohistochemistry
• Lung Neoplasms (metabolism, pathology, surgery)
• Transcription Factors