Abstract | UNLABELLED: BACKGROUND: METHODS: 120 patients were randomly divided into two equal groups. In group A, bicarbonate was infused intra-operatively according to Base Excess (BE) measurements to achieve the normal values of BE (-5 to +5 mEq/L). In group B, infusion of bicarbonate was allowed only in case of severe metabolic acidosis (BE ≤ -15 mEq/L or bicarbonate ≤ 10 mEq/L or PH ≤ 7.15). Minute ventilation was adjusted to keep PaCO2 within the normal range. Primary end-point was sampling of serum creatinine level in first, second, third and seventh post-operative days for statistical comparison between groups. Secondary objectives were comparison of cumulative urine volumes in the first 24 h of post-operative period and serum BUN levels which were obtained in first, second, third and seventh post-operative days. RESULTS: In group A, all of consecutive serum creatinine levels were significantly lower in comparison with group B. With regard to secondary outcomes, no significant difference between groups was observed. CONCLUSION:
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Authors | Farhad Etezadi, Pejman Pourfakhr, Mojtaba Mojtahedzade, Atabak Najafi, Reza Shariat Moharari, Kourosh Karimi Yarandi, Mohammad Reza Khajavi |
Journal | Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
(Daru)
Vol. 20
Issue 1
Pg. 36
(Sep 10 2012)
ISSN: 1560-8115 [Print] Switzerland |
PMID | 23351673
(Publication Type: Journal Article)
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