Abstract | BACKGROUND: OBJECTIVE: To examine the relationships between lipid and nonlipid factors and lipoprotein subfractions in infants at birth and follow-up (FU) and in their parents. METHODS: Prospective study in a community-based hospital of 103 families ascertained through a pregnant mother at 36 weeks gestation or older. Of 103 infants studied at birth, 85 were sampled at FU at 2-3 months of age, along with 76 fathers. Lipids, lipoproteins, and their subclasses were determined by nuclear magnetic resonance spectroscopy. Correlations of lipid-related parameters were calculated using Spearman rank correlations. RESULTS: Female gender in infants and use of formula only were the only nonlipid variables associated with lipoprotein subfractions. LDL parameters were significantly correlated between infants at birth and FU. The largest high-density lipoprotein subfraction, H5C, was the only lipid variable significantly associated between mothers and infants at birth. Paternal low-density lipoprotein size was significantly correlated with that of infants at FU but not at birth. In each of the four groups, markedly inverse interrelationships were found between H5C and small LDL particles. At birth and at FU, apoC-I was strongly related with H5C but not TG. Conversely, apoC-I in the parents was strongly related with TG but not H5C. CONCLUSION:
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Authors | Peter O Kwiterovich, Donna G Virgil, Audrey Y Chu, Victor A Khouzami, Petar Alaupovic, James D Otvos |
Journal | Journal of clinical lipidology
(J Clin Lipidol)
2013 Jan-Feb
Vol. 7
Issue 1
Pg. 29-37
ISSN: 1933-2874 [Print] United States |
PMID | 23351580
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Apolipoprotein C-I
- Lipoproteins, HDL
- Triglycerides
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Topics |
- Adult
- Apolipoprotein C-I
(blood)
- Blood Chemical Analysis
- Body Mass Index
- Cardiovascular Diseases
(blood, pathology)
- Female
- Follow-Up Studies
- Gestational Age
- Hospitals, Community
- Humans
- Infant
- Infant, Newborn
- Lipoproteins, HDL
(blood, chemistry)
- Magnetic Resonance Spectroscopy
- Male
- Mothers
- Parents
- Pregnancy
- Prospective Studies
- Risk Factors
- Triglycerides
(blood)
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