Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjects.

Abstract

Non-fasting triglyceridemia is much closer associated to cardiovascular risk compared to fasting triglyceridemia. We hypothesized that there would be acute differential effects of four common dietary proteins (cod protein, whey isolate, gluten, and casein) on postprandial lipemia in obese non-diabetic subjects. To test the hypothesis we conducted a randomized, acute clinical intervention study with crossover design. We supplemented a fat rich mixed meal with one of four dietary proteins i.e. cod protein, whey protein, gluten or casein. Eleven obese non-diabetic subjects (age: 40-68, body mass index: 30.3-42.0 kg/m(2)) participated and blood samples were drawn in the 8-h postprandial period. Supplementation of a fat rich mixed meal with whey protein caused lower postprandial lipemia (P = .048) compared to supplementation with cod protein and gluten. This was primarily due to lower triglyceride concentration in the chylomicron rich fraction (P = .0293). Thus, we have demonstrated acute differential effects on postprandial metabolism of four dietary proteins supplemented to a fat rich mixed meal in obese non-diabetic subjects. Supplementation with whey protein caused lower postprandial lipemia compared to supplementation with cod and gluten. As postprandial lipemia is closely correlated to cardiovascular disease, long-term dietary supplementation with whey protein may prove beneficial in preventing cardiovascular disease in obese non-diabetic subjects.

• Authors: Jens Holmer-Jensen, Lene S Mortensen, Arne Astrup, Michael de Vrese, Jens J Holst, Claus Thomsen, Kjeld Hermansen
• Journal: Nutrition research (New York, N.Y.) (Nutr Res) Vol. 33 Issue 1 Pg. 34-40 (Jan 2013) ISSN: 1879-0739 [Electronic] United States
• PMID: 23351408 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Blood Glucose
• Caseins
• Dietary Proteins
• Fatty Acids, Nonesterified
• Milk Proteins
• Triglycerides
• Whey Proteins
• Glutens

Topics

• Adult
• Aged
• Blood Glucose (analysis)
• Body Mass Index
• Cardiovascular Diseases (prevention & control)
• Caseins (administration & dosage)
• Cross-Over Studies
• Diabetes Mellitus
• Dietary Proteins (administration & dosage)
• Fatty Acids, Nonesterified (blood)
• Female
• Glutens (administration & dosage)
• Humans
• Hyperlipidemias (blood, etiology)
• Life Style
• Male
• Meals
• Middle Aged
• Milk Proteins (administration & dosage)
• Obesity (blood, complications)
• Postprandial Period (drug effects)
• Triglycerides (blood)
• Whey Proteins