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Cytotoxic constituents of ethyl acetate fraction from Dianthus superbus.

Abstract
The ethyl acetate fraction (EE-DS) from Dianthus superbus was found to possess the cytotoxic activity against cancer cells in previous study. To investigate cytotoxic constituents, the bioassay-guided isolation of compounds from EE-DS was performed. Two dianthramides (1 and 2), three flavonoids (3-5), two coumarins (6 and 7) and three other compounds (8-10) were obtained. Structures of isolated compounds were identified by spectroscopic analysis. Cytotoxicity of the compounds against HepG2 cells was evaluated. Compound 1 showed the strongest cytotoxicity, compounds 10, 4, 3 and 5 had moderate cytotoxicity.
AuthorsChengli Ding, Wu Zhang, Jie Li, Jiachuan Lei, Jianqing Yu
JournalNatural product research (Nat Prod Res) Vol. 27 Issue 18 Pg. 1691-4 ( 2013) ISSN: 1478-6427 [Electronic] England
PMID23351147 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Acetates
  • Coumarins
  • Flavonoids
  • Plant Extracts
  • ethyl acetate
Topics
  • Acetates (chemistry)
  • Cell Survival (drug effects)
  • Coumarins (chemistry)
  • Dianthus (chemistry)
  • Flavonoids (chemistry)
  • Hep G2 Cells
  • Humans
  • Plant Extracts (chemistry)

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