Abstract |
The ethyl acetate fraction (EE-DS) from Dianthus superbus was found to possess the cytotoxic activity against cancer cells in previous study. To investigate cytotoxic constituents, the bioassay-guided isolation of compounds from EE-DS was performed. Two dianthramides (1 and 2), three flavonoids (3-5), two coumarins (6 and 7) and three other compounds (8-10) were obtained. Structures of isolated compounds were identified by spectroscopic analysis. Cytotoxicity of the compounds against HepG2 cells was evaluated. Compound 1 showed the strongest cytotoxicity, compounds 10, 4, 3 and 5 had moderate cytotoxicity.
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Authors | Chengli Ding, Wu Zhang, Jie Li, Jiachuan Lei, Jianqing Yu |
Journal | Natural product research
(Nat Prod Res)
Vol. 27
Issue 18
Pg. 1691-4
( 2013)
ISSN: 1478-6427 [Electronic] England |
PMID | 23351147
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetates
- Coumarins
- Flavonoids
- Plant Extracts
- ethyl acetate
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Topics |
- Acetates
(chemistry)
- Cell Survival
(drug effects)
- Coumarins
(chemistry)
- Dianthus
(chemistry)
- Flavonoids
(chemistry)
- Hep G2 Cells
- Humans
- Plant Extracts
(chemistry)
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