Churg-Strauss syndrome presenting with focal segmental glomerulosclerosis without proteinuria: response to unconventional therapy.

Abstract

Churg-Strauss syndrome (CSS), or allergic granulomatosis, is a rare disease manifested by tissue infiltration, hypereosinophilia and vasculitis. Renal involvement may be seen in up to 50% of cases. We report the case of a 25-year old man who presented with a history of fever for two months, tingling, numbness, and paraesthesia of the upper limbs and left lower limb, along with diarrhoea for one month and an inability to walk for the past seven days. Serial laboratory investigations helped to reach the final diagnosis of CSS with mononeuritis multiplex, and skin, pulmonary and gastrointestinal involvement with hypertension. This is due to renal involvement in the form of focal segmental glomerulosclerosis without any nephrotic range proteinuria, which is a very rare clinical entity. The patient's symptoms were relieved after the administration of an unconventional mode of therapy.

• Authors: Pradipta Guha, Indranil Thakur, Arindam Ray, Sanjoy Kumar Chatterjee
• Journal: Singapore medical journal (Singapore Med J) Vol. 54 Issue 1 Pg. e13-5 (Jan 2013) ISSN: 0037-5675 [Print] India
• PMID: 23338924 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Biopsy
• Churg-Strauss Syndrome (complications, diagnosis)
• Fever
• Glomerulosclerosis, Focal Segmental (complications, diagnosis)
• Humans
• Kidney (pathology)
• Kidney Diseases (complications)
• Male
• Proteinuria (diagnosis)
• Radiography, Thoracic
• Skin (pathology)
• Treatment Outcome