HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Retinal vein occlusion: genetic predisposition and systemic risk factors.

Abstract
The role of systemic risk factors (age, smoking, diabetes, arterial hypertension) in the development of retinal vein occlusion (RVO) is well established. However, the association of RVO with genetic predisposition to thrombosis remains poorly understood. The aim of the study was to assess any possible additional effect of genetic predisposition to the already well known 'classical' risk factors of RVO in a cohort of elderly Greek patients. Fifty-one elderly patients with RVO and 51 healthy individuals matched for age and sex were evaluated for systemic risk factors (smoking, diabetes, dyslipidemia, arterial hypertension) and coagulation defects (lupus anticoagulant, natural inhibitors of coagulation). Additionally, genotyping was performed for mutations/polymorphisms involved in haemostasis such as: FV G1691A, FV G4070A, FIIG 20210A, MTHFR C677T and A1298C, PAI-1-675 4G/5G, F XIII exon 2G/T, EPCR A4600G and G4678C. We identified systemic risk factors in the majority of the patients Hypertension (P=0.001), dyslipidemia (P=0.029) and diabetes (P=0.01) are associated with RVO in the majority of the patients. The prevalence of prothrombotic risk factors was not significantly different in the patients with RVO compared to controls. Apart from systemic risk factors, genetic predisposition to thrombosis does not seem to have an important association with RVO in this group of elderly patients.
AuthorsKassiani Giannaki, Marianna Politou, Alexandros Rouvas, Efrossyni Merkouri, Anthi Travlou, Panayiotis Theodosiadis, Argyri Gialeraki
JournalBlood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis (Blood Coagul Fibrinolysis) Vol. 24 Issue 3 Pg. 279-83 (Apr 2013) ISSN: 1473-5733 [Electronic] England
PMID23337712 (Publication Type: Journal Article)
Chemical References
  • Blood Coagulation Factors
  • Lupus Coagulation Inhibitor
Topics
  • Aged
  • Aged, 80 and over
  • Blood Coagulation Factors (genetics)
  • Diabetes Complications
  • Diabetes Mellitus (genetics, pathology)
  • Dyslipidemias (complications, genetics, pathology)
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Hypertension (complications, genetics, pathology)
  • Lupus Coagulation Inhibitor (blood)
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Retinal Vein Occlusion (complications, genetics, pathology)
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: