Abstract | BACKGROUND: METHODS: Four- to six-week-old male specific pathogen-free BALB/c mice were inoculated intranasally with 10(5) 50% tissue culture infective doses (TCID50) of highly pathogenic A/Chicken/Hebei/108/2002 (H5N1) viruses and were then given 1000 IU of lauric acid modified superoxide dismutase (LA-SOD) by intraperitoneal injection, starting 2 days post- infection and continuing for 6 days. RESULTS: The extent of lung injury and the concentration of OFRs were higher, and the SOD activity was lower in H5N1 virus-infected mice than that in uninfected control mice on days 3, 6, and 7 post-inoculation. Weak amelioration of clinical signs, a minor decrease in the total mortality and the extent of lung injury, and the lower OFRs concentration were seen in the LA-SOD treatment group, but a reduction in lung virus titers was not observed in the LA-SOD treatment at all time points. CONCLUSIONS: The LA-SOD treatment has a mild inhibitory effect on H5N1 influenza virus infection in mice. OFRs, therefore, might play an important role in the pathogenesis of acute lung injury induced by H5N1 virus.
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Authors | Guimei He, Changgui Dong, Zhihua Luan, Bronwyn M McAllan, Tong Xu, Lihong Zhao, Jian Qiao |
Journal | Influenza and other respiratory viruses
(Influenza Other Respir Viruses)
Vol. 7
Issue 6
Pg. 945-53
(Nov 2013)
ISSN: 1750-2659 [Electronic] England |
PMID | 23336583
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Acute Lung Injury
- Animals
- Disease Models, Animal
- Free Radicals
(toxicity)
- Influenza A Virus, H5N1 Subtype
(physiology)
- Lung
(pathology, virology)
- Male
- Mice
- Mice, Inbred BALB C
- Orthomyxoviridae Infections
(immunology, pathology, virology)
- Survival Analysis
- Viral Load
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