Evaluation of GLUT-1 in the granular cell tumour and congenital granular cell epulis.

Abstract

BACKGROUND:

The glucose transporter type 1 (GLUT-1) protein is a useful marker for perineurial cells. Because of the possible neuroectodermal histogenesis of the granular cell tumour and congenital granular cell epulis, the aim of this study was to assess the immunoexpression of GLUT-1 protein in granular cell tumour and congenital granular cell epulis to aid in clarifying their histogenesis.

METHODS:

The protocol of this study was approved by the Committee of Bioethics in Research at Universidade Federal Minas Gerais. Six cases of granular cell tumour and three cases of congenital granular cell epulis were submitted to immunohistochemistry for GLUT-1 and S-100 using the streptavidin-biotin standard protocol.

RESULTS:

Five cases of granular cell tumour were located on the tongue and one case on the upper lip. All cases of congenital granular cell epulis were observed in the alveolar ridge of newborns. All lesions evaluated proved to be immunonegative for GLUT-1. S-100 was found to be positive in all granular cell tumours and negative in congenital granular cell epulis.

CONCLUSIONS:

Neither granular cell tumour nor congenital granular cell epulis is directly related to perineurial cells.

• Authors: Giovanna Ribeiro Souto, Patrícia Carlos Caldeira, Aline Cristina Batista Rodrigues Johann, Helenicede Andrade Marigo, Suzana Cantanhede Orsini Machadode Souza, Ricardo Alves Mesquita
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 42 Issue 6 Pg. 450-3 (Jul 2013) ISSN: 1600-0714 [Electronic] Denmark
• PMID: 23336292 (Publication Type: Journal Article)
• Copyright: © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Glucose Transporter Type 1
• S100 Proteins
• SLC2A1 protein, human

Topics

• Adult
• Female
• Gingival Neoplasms (congenital, pathology)
• Glucose Transporter Type 1 (analysis)
• Granular Cell Tumor (pathology)
• Humans
• Immunohistochemistry
• Infant, Newborn
• Lip Neoplasms (pathology)
• Male
• Middle Aged
• Neural Plate (pathology)
• Peripheral Nerves (pathology)
• S100 Proteins (analysis)
• Tongue Neoplasms (pathology)