[Study on the association between RANTES-403G/A as well as -28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou, China].

Abstract

OBJECTIVE:

To investigate the association between both regulated upon activation normal T cell expressed and secreted (RANTES) -403G/A, -28C/G gene polymorphism and the susceptibilities to hepatitis B virus (HBV) infection, among people with Dong and Han ethnicities, in Guizhou.

METHODS:

A total of 229 individuals with HBV persistence infection, 161 HBV clearanced patients and another 200 controls were recruited to conduct a case-control study among residents with Dong or Han ethnicities. Allelic frequencies of both RANTES-403G/A and -28C/G were identified by TaqMan-MGB probe.

RESULTS:

Both RANTES-403G/A and -28C/G polymorphism in the HBV-persistent group, when compared to the HBV-clearances group, no significant difference was found (P > 0.05).

RESULTS:

from the univariate analysis showed that subjects carrying -403AG and -28GG genotype had higher risk on the susceptibility to HBV persistence infection. The distributions of RANTES-28C/G gene polymorphism between Dong minority and Han ethnicities regarding HBV persistence showed statistically significant difference (P < 0.05). There was no difference on the distributions of RANTES-403G/A gene polymorphism between Dong minority and Han ethnicities.

CONCLUSION:

Patients that carrying both RANTES-403AG and -28GG genotype had higher risk on the persistence to HBV, while RANTES-403A had contributed to the clearance of HBV infection.

• Authors: Chan Zhang, Ke-ren Shan, Yan He, Chan-juan Wang, Ting Zhang, Yi Li, Jie Deng, Lin-jie Li, Kai Ouyang, Zhi-zhong Guan
• Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi (Zhonghua Liu Xing Bing Xue Za Zhi) Vol. 33 Issue 12 Pg. 1279-82 (Dec 2012) ISSN: 0254-6450 [Print] China
• PMID: 23336202 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CCL5 protein, human
• Chemokine CCL5

Topics

• Case-Control Studies
• Chemokine CCL5 (genetics)
• China (epidemiology)
• Ethnicity (genetics)
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Hepatitis B (epidemiology, genetics)
• Hepatitis B virus
• Humans
• Polymorphism, Single Nucleotide