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Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation.

Abstract
Intracellular Flightless I (Flii), a gelsolin family member, has been found to have roles modulating actin regulation, transcriptional regulation and inflammation. In vivo Flii can regulate wound healing responses. We have recently shown that a pool of Flii is secreted by fibroblasts and macrophages, cells typically found in wounds, and its secretion can be upregulated upon wounding. We show that secreted Flii can bind to the bacterial cell wall component lipopolysaccharide and has the potential to regulate inflammation. We now show that secreted Flii is present in both acute and chronic wound fluid.
AuthorsAllison J Cowin, Nazi Lei, Linda Franken, Nadira Ruzehaji, Carolin Offenhäuser, Zlatko Kopecki, Rachael Z Murray
JournalCommunicative & integrative biology (Commun Integr Biol) Vol. 5 Issue 6 Pg. 546-9 (Nov 01 2012) ISSN: 1942-0889 [Print] United States
PMID23336022 (Publication Type: Journal Article)

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