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The impact of oxidative stress in thiamine deficiency: a multifactorial targeting issue.

Abstract
Thiamine (vitamin B1) deficiency, the underlying cause of Wernicke-Korsakoff syndrome, is associated with the development of focal neuronal loss in vulnerable areas of the brain. Although the actual mechanism(s) that lead to the selective histological lesions characteristic of this disorder remain unresolved, oxidative stress has been shown to play a major role in its pathophysiology. In this review, the multifactorial influence of oxidative stress on a variety of processes known to take part in the development of structural lesions in TD including excitotoxicity, neuroinflammation, blood-brain barrier integrity, mitochondrial integrity, apoptosis, nucleic acid function, and neural stem cells will be discussed, and therapeutic strategies undertaken for treating neurodegeneration examined which may have an impact on the future treatment of this important vitamin deficiency.
AuthorsAlan S Hazell, Samantha Faim, Guilherme Wertheimer, Vinicius R Silva, Cleiton S Marques
JournalNeurochemistry international (Neurochem Int) Vol. 62 Issue 5 Pg. 796-802 (Apr 2013) ISSN: 1872-9754 [Electronic] England
PMID23333339 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Topics
  • Animals
  • Apoptosis
  • Blood-Brain Barrier
  • Humans
  • Mitochondria (metabolism)
  • Oxidative Stress
  • Thiamine Deficiency (metabolism)

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