Efficacy of topical calcineurin inhibitors in vitiligo.

Abstract

Topical tacrolimus and pimecrolimus are indicated for the treatment of atopic dermatitis, but they have been studied in many off-label uses. We reviewed the English language literature to define their roles in treatment of vitiligo. Double-blind studies show that tacrolimus 0.1% ointment combined with excimer laser is superior to placebo, especially for UV resistant areas, such as bony prominences of the extremities. When used alone, tacrolimus 0.1% ointment is almost as effective as clobetasol propionate 0.05% ointment. Other studies suggest it can also be effective for facial lesions. Double blind studies show that pimecrolimus 1% cream combined with narrow band UVB is superior to placebo, especially for facial lesions. Additional studies would further clarify the role of topical calcineurin inhibitors in vitiligo.

• Authors: Russell Wong, Andrew N Lin
• Journal: International journal of dermatology (Int J Dermatol) Vol. 52 Issue 4 Pg. 491-6 (Apr 2013) ISSN: 1365-4632 [Electronic] England
• PMID: 23331250 (Publication Type: Journal Article, Review)
• Copyright: © 2013 The International Society of Dermatology.

Chemical References

• Calcineurin Inhibitors
• Dermatologic Agents
• Ointments
• pimecrolimus
• Tacrolimus

Topics

• Administration, Cutaneous
• Calcineurin Inhibitors
• Dermatologic Agents (administration & dosage, therapeutic use)
• Humans
• Ointments
• Skin Cream (therapeutic use)
• Tacrolimus (administration & dosage, analogs & derivatives, therapeutic use)
• Vitiligo (drug therapy)