Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review.

Diabetic ketoacidosis is a life-threatening complication of Type 1 diabetes. Blood β-hydroxybutyrate testing is now widely available as an alternative to urine acetoacetate testing for detecting ketosis. The aim of this study was to review the effectiveness of capillary or serum β-hydroxybutyrate compared with urine acetoacetate testing in prevention and management of diabetic ketoacidosis.
MEDLINE, EMBASE, EBM Reviews, The Cochrane Library and CINAHL (until April 2012, no language restrictions, studies in humans) were searched for experimental and observational studies comparing the effectiveness of blood β-hydroxybutyrate and urine acetoacetate testing. Outcomes examined were prevention of diabetic ketoacidosis, time to recovery from diabetic ketoacidosis, healthcare costs and patient or caregiver satisfaction. Additional sources included reference lists, conference proceedings and contact with experts in the field.
Four studies (two randomized controlled trials and two cohort studies) met eligibility criteria, including 299 participants across 11 centres. Risk of bias was low to moderate. Blood ketone testing compared with urine testing was associated with reduced frequency of hospitalization (one study), reduced time to recovery from diabetic ketoacidosis (three studies), cost benefits (one study) and greater satisfaction (one study, intervention group only). No study assessed prevention of diabetic ketoacidosis. Meta-analysis could not be performed because of heterogeneity in study design and published data.
There is evidence suggesting that blood β-hydroxybutyrate testing is more effective than urine acetoacetate testing in reducing emergency department assessment, hospitalization and time to recovery from diabetic ketoacidosis, as well as potentially lowering healthcare expenditure. Further research in both young people and adults is needed.
AuthorsA A Klocker, H Phelan, S M Twigg, M E Craig
JournalDiabetic medicine : a journal of the British Diabetic Association (Diabet Med) Vol. 30 Issue 7 Pg. 818-24 (Jul 2013) ISSN: 1464-5491 [Electronic] England
PMID23330615 (Publication Type: Comparative Study, Journal Article, Review)
Copyright© 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK.
Chemical References
  • Acetoacetates
  • acetoacetic acid
  • 3-Hydroxybutyric Acid
  • 3-Hydroxybutyric Acid (blood)
  • Acetoacetates (urine)
  • Critical Care (economics)
  • Crown-Rump Length
  • Diabetes Mellitus, Type 1 (complications)
  • Diabetic Ketoacidosis (economics, prevention & control, therapy)
  • Health Expenditures
  • Hospitalization (economics)
  • Humans
  • Randomized Controlled Trials as Topic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: