Olanzapine treatment for tics in an adult woman with severe tourette syndrome.

Abstract

PURPOSE:

Olanzapine had been reported to be effective in the control of tics in a few adult female patients who had a short follow-up period. The author reports the successful outcome of long-term olanzapine treatment in an adult woman with severe Tourette syndrome.

CASE REPORT:

A 33-year-old woman who had severe motor and vocal tics (Modified Rush Videotape Rating Scale: 17/20) showed an excellent response to olanzapine 10 mg/day within 2 months. Her tic symptoms were well controlled with gradual reduction of her dose of olanzapine to 2.5 mg/day during the following 8 years. She was symptom-free without medications in the past 2 years. In addition, she had a normal menstrual cycle and became pregnant during the period of olanzapine treatment.

CONCLUSION:

Olanzapine may be the drug of first choice for treating severe Tourette syndrome in pubescent female adolescents and young women who wish to have children.

• Authors: Wen-Juh Hwang
• Journal: Acta neurologica Taiwanica (Acta Neurol Taiwan) Vol. 21 Issue 4 Pg. 165-8 (Dec 2012) ISSN: 1028-768X [Print] China (Republic : 1949- )
• PMID: 23329547 (Publication Type: Case Reports, Journal Article)

Chemical References

• Serotonin Uptake Inhibitors
• Benzodiazepines
• Olanzapine

Topics

• Adult
• Benzodiazepines (therapeutic use)
• Female
• Follow-Up Studies
• Humans
• Olanzapine
• Selective Serotonin Reuptake Inhibitors (therapeutic use)
• Severity of Illness Index
• Tics (drug therapy, etiology)
• Tourette Syndrome (complications)