Abstract | UNLABELLED:
Coagulase-negative staphylococci are the most common cause of late-onset sepsis in premature neonates. The optimal approach in persistent coagulase-negative staphylococcal bacteremia, despite adequate treatment with glycopeptides, is not well established. A retrospective study was conducted on preterm neonates with persistent coagulase-negative staphylococcal bacteremia treated with the combination of vancomycin- rifampicin. Ten cases were included, with a median gestational age of 26 weeks (range 24 weeks + 3 days-31 weeks + 4 days, interquartile range 25 weeks + 3 days-29 weeks + 3 days) and a median birth weight of 715 g (range 555-2,030). The median age at the onset of infection was 9 days (range 5-37). The most frequent clinical presentation was apnea or increased ventilatory support. Bacteremia persisted for a median of 9 (range 6-19) days until rifampicin initiation. Bacteremia was resolved in all cases on vancomycin- rifampicin with no serious side effects. CONCLUSION:
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Authors | Luciana Rodriguez-Guerineau, María Dolors Salvia-Roigés, Marisol León-Lozano, José Manuel Rodríguez-Miguélez, Josep Figueras-Aloy |
Journal | European journal of pediatrics
(Eur J Pediatr)
Vol. 172
Issue 5
Pg. 693-7
(May 2013)
ISSN: 1432-1076 [Electronic] Germany |
PMID | 23328960
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Coagulase
- Vancomycin
- Rifampin
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Topics |
- Anti-Bacterial Agents
(therapeutic use)
- Bacteremia
(drug therapy, microbiology)
- Coagulase
- Drug Therapy, Combination
- Female
- Humans
- Infant, Newborn
- Infant, Premature
- Male
- Retrospective Studies
- Rifampin
(therapeutic use)
- Staphylococcal Infections
(drug therapy)
- Staphylococcus
(drug effects)
- Treatment Outcome
- Vancomycin
(therapeutic use)
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