New insight into the treatment of advanced differentiated thyroid cancer.

Abstract

The vast majority of patients with differentiated thyroid cancer (DTC) are treated successfully with surgery and radioactive iodine ablation, yet the treatment of advanced cases is frustrating and largely ineffective. Systemic treatment with conventional cytotoxic chemotherapy is basically ineffective in most patients with advanced DTC. However, a better understanding of the genetics and biologic basis of thyroid cancers has generated opportunities for innovative therapeutic modalities, resulting in several clinical trials. We aim to delineate the latest knowledge regarding the biologic characteristics of DTC and to describe the available data related to novel targeted therapies that have demonstrated clinical effectiveness.

• Authors: Arash Safavi, Aparna Vijayasekaran, Marlon A Guerrero
• Journal: Journal of thyroid research (J Thyroid Res) Vol. 2012 Pg. 437569 ( 2012) ISSN: 2042-0072 [Electronic] United States
• PMID: 23326755 (Publication Type: Journal Article)