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Outcome of screening endoscopy in common variable immunodeficiency disorder and X-linked agammaglobulinemia.

Abstract
Gastrointestinal symptoms are common in patients with common variable immunodeficiency disorders (CVID) and less frequent in X-linked agammaglobulinemia (XLA) although the exact prevalence is not well established. In this study, endoscopic screening was performed in 30 patients with CVID and four patients with XLA. Endoscopic and/or histological abnormalities were detected in 25 of 30 patients with CVID (83 %), regardless of symptoms, and in nine of these patients the results prompted medical treatment. Helicobacter pylori-associated gastritis, adenomatous polyps, and lymphoid hyperplasia were most frequently encountered; no malignancies were detected. Adenomatous polyps were found in two of the four patients with XLA at a relative young age. In conclusion, gastrointestinal pathology is frequent in patients with CVID regardless of symptoms. Patients with XLA seem to be at risk for colorectal adenomas at a young age.
AuthorsL J Maarschalk-Ellerbroek, B Oldenburg, I M H Mombers, A I M Hoepelman, L A A Brosens, G J A Offerhaus, P M Ellerbroek
JournalEndoscopy (Endoscopy) Vol. 45 Issue 4 Pg. 320-3 ( 2013) ISSN: 1438-8812 [Electronic] Germany
PMID23325698 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© Georg Thieme Verlag KG Stuttgart · New York.
Topics
  • Adenomatous Polyps (complications, diagnosis)
  • Adolescent
  • Adult
  • Agammaglobulinemia (complications)
  • Aged
  • Colonoscopy
  • Colorectal Neoplasms (complications, diagnosis)
  • Common Variable Immunodeficiency (complications)
  • Cross-Sectional Studies
  • Female
  • Gastritis (complications, diagnosis, microbiology)
  • Gastroscopy
  • Genetic Diseases, X-Linked (complications)
  • Helicobacter Infections (diagnosis)
  • Helicobacter pylori
  • Humans
  • Male
  • Middle Aged
  • Population Surveillance
  • Pseudolymphoma (complications, diagnosis)
  • Young Adult

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