Abstract | BACKGROUND: Due to high health care costs of venous thromboembolism (VTE), economic analyses are needed to determine the efficiency of different drug treatments. Consequently, a study was conducted to estimate the budgetary impact for the National Health System (NHS) with apixaban for prevention of venous thromboembolism (VTE) in total hip (THR) or knee (TKR) replacement. METHODS: TIME HORIZON: 5 years. All costs were discounted by 3.5% annually. Five years after commercialization, the use of apixaban was estimated to account for 23% of the prophylaxis of VTE and the use of enoxaparin decrease from the 60% to 33%. RESULTS: Apixaban´s introduction for the prophylaxis of VTE would have a significant impact for the NHS, resulting in a saving of 547,422 Euro over a period of 5 years. In the case of outpatient administration of heparin did not have a cost, the savings for the NHS five years amount to 270,068 Euro. CONCLUSIONS: According to this study, the introduction of apixaban may reduce the rate of VTE and bleeding compared with enoxaparin, decreasing the expenditure of NHS in VTE prophylaxis.
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Authors | Inmaculada Gómez Arrayas, Carmen Suárez Fernández, Jorge F Gómez Cerezo, Lourdes Betegón Nicolás, Marina de Salas-Cansado, Carlos Rubio-Terrés |
Journal | Revista espanola de salud publica
(Rev Esp Salud Publica)
Vol. 86
Issue 6
Pg. 601-12
(Dec 2012)
ISSN: 2173-9110 [Electronic] Spain |
Vernacular Title | Impacto presupuestario para el Sistema Nacional de Salud de la prevención del trombolismo venoso con apixaban en pacientes sometidos a artroplastia total de rodilla o cadera. |
PMID | 23325135
(Publication Type: Journal Article)
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Chemical References |
- Anticoagulants
- Benzimidazoles
- Enoxaparin
- Fibrinolytic Agents
- Morpholines
- Polysaccharides
- Pyrazoles
- Pyridones
- Thiophenes
- beta-Alanine
- apixaban
- Rivaroxaban
- Dabigatran
- Fondaparinux
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Topics |
- Aged
- Anticoagulants
(economics, therapeutic use)
- Arthroplasty, Replacement, Hip
(adverse effects)
- Arthroplasty, Replacement, Knee
(adverse effects)
- Benzimidazoles
(economics, therapeutic use)
- Budgets
- Cost Control
(economics)
- Dabigatran
- Enoxaparin
(economics, therapeutic use)
- Female
- Fibrinolytic Agents
(economics, therapeutic use)
- Fondaparinux
- Hemorrhage
(drug therapy, economics)
- Humans
- Morpholines
(economics, therapeutic use)
- Polysaccharides
(economics, therapeutic use)
- Pulmonary Embolism
(drug therapy, economics)
- Pyrazoles
(economics, therapeutic use)
- Pyridones
(economics, therapeutic use)
- Rivaroxaban
- Spain
- State Medicine
(economics)
- Thiophenes
(economics, therapeutic use)
- Venous Thromboembolism
(etiology, prevention & control)
- beta-Alanine
(analogs & derivatives, economics, therapeutic use)
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