HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Impairment of sympathetic activation during static exercise in patients with muscle phosphorylase deficiency (McArdle's disease).

Abstract
Static exercise in normal humans causes reflex increases in muscle sympathetic nerve activity (MSNA) that are closely coupled to the contraction-induced decrease in muscle cell pH, an index of glycogen degradation and glycolytic flux. To determine if sympathetic activation is attenuated when muscle glycogenolysis is blocked due to myophosphorylase deficiency (McArdle's disease), an inborn enzymatic defect localized to skeletal muscle, we now have performed microelectrode recordings of MSNA in four patients with McArdle's disease during static handgrip contraction. A level of static handgrip that more than doubled MSNA in normal humans had no effect on MSNA and caused an attenuated rise in blood pressure in the patients with myophosphorylase deficiency. In contrast, two nonexercise sympathetic stimuli, Valsalva's maneuver and cold pressor stimulation, evoked comparably large increases in MSNA in patients and normals. The principal new conclusion is that defective glycogen degradation in human skeletal muscle is associated with a specific reflex impairment in sympathetic activation during static exercise.
AuthorsS L Pryor, S F Lewis, R G Haller, L A Bertocci, R G Victor
JournalThe Journal of clinical investigation (J Clin Invest) Vol. 85 Issue 5 Pg. 1444-9 (May 1990) ISSN: 0021-9738 [Print] United States
PMID2332499 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Phosphates
  • Phosphocreatine
  • Adenosine Diphosphate
  • Phosphorylases
Topics
  • Adenosine Diphosphate (metabolism)
  • Adult
  • Glycogen Storage Disease Type V (physiopathology)
  • Humans
  • Hydrogen-Ion Concentration
  • Magnetic Resonance Spectroscopy (methods)
  • Muscles (enzymology, innervation, physiopathology)
  • Phosphates (metabolism)
  • Phosphocreatine (metabolism)
  • Phosphorylases (deficiency)
  • Physical Exertion
  • Reference Values
  • Sympathetic Nervous System (physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: