Clinical remission following plasmapheresis and corticosteroid treatment in a dog with acquired myasthenia gravis.

Abstract

A 7-year-old sexually intact male Labrador Retriever with regurgitation and generalized muscular weakness resulting from acquired myasthenia gravis received 2 plasmapheresis treatments in combination with corticosteroid treatment. Plasmapheresis was performed in an attempt to rapidly lower serum acetylcholine receptor binding antibody (AChR Ab) concentration. Seven days after the second plasmapheresis treatment, the dog's muscular strength was normal, which coincided with a 70% decrease in serum AChR Ab concentration. Because the dog also received corticosteroids, it is impossible to determine how much of the clinical improvement resulted from plasmapheresis.

• Authors: J W Bartges, J S Klausner, E F Bostwick, J E Hakala, V A Lennon
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 196 Issue 8 Pg. 1276-8 (Apr 15 1990) ISSN: 0003-1488 [Print] United States
• PMID: 2332375 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Prednisone

Topics

• Animals
• Combined Modality Therapy
• Dog Diseases (therapy)
• Dogs
• Male
• Myasthenia Gravis (therapy, veterinary)
• Plasmapheresis (veterinary)
• Prednisone (therapeutic use)