Clinical significance of CA19-9 in the follow-up of colorectal cancer patients with elevated preoperative serum CA19-9.

Abstract

BACKGROUND/AIMS:

We hypothesized an advantage of using carbohydrate antigen 19-9 (CA19-9) over carcinoembryonic antigen (CEA) in postoperative surveillance of colorectal cancer (CRC) patients with elevated preoperative serum CA19-9 (PreCA19-9).

METHODOLOGY:

We analyzed 197 CRC patients with elevated PreCA19-9 (>=37U/mL). Serum levels of CEA and CA19-9 were monitored postoperatively, according to standard protocol. IndexCEA and IndexCA19-9 were defined as the levels of CEA and CA19-9, respectively, recorded at recurrence confirmation or at the last follow-up of non-recurrence.

RESULTS:

There were 56 recurrences during follow-up. IndexCA19-9 (cut-off, 38.6U/mL) had better sensitivity (0.80 vs. 0.68) and specificity (0.87 vs. 0.83) than did IndexCEA (cut-off. 2.8ng/mL). Area under the curve (AUC) analysis revealed that although IndexCA19-9 (0.90; 95% confidence interval [CI], 0.84-0.95) had better coverage than IndexCEA (0.84; 95% CI, 0.78-0.90), there was no significant difference (p=0.085). With the progressive rising of PreCA19-9 levels, we observed the trend of better AUC performance of IndexCA19-9 over IndexCEA. At a cut-off of 42U/mL for PreCA19-9, IndexCA19-9 began to have significantly better coverage than IndexCEA (p=0.027).

CONCLUSION:

The surveillance advantage of CA19-9 over CEA was shown in the group of patients with preoperative CA19-9 levels >42U/mL.

• Authors: Shung-Haur Yang, Jeng-Kai Jiang, Shih-Ching Chang, Chi-Jung Juang, Jen-Kou Lin
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2013 Jul-Aug Vol. 60 Issue 125 Pg. 1021-7 ISSN: 0172-6390 [Print] Greece
• PMID: 23321120 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CA-19-9 Antigen
• Carcinoembryonic Antigen

Topics

• Adult
• Aged
• Area Under Curve
• CA-19-9 Antigen (blood)
• Carcinoembryonic Antigen (blood)
• Colorectal Neoplasms (blood)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged