Efficacy of cyclosporin A for idiopathic pulmonary fibrosis.

Abstract

In an 11-year-old girl with severe dyspnoea and cyanosis, idiopathic pulmonary fibrosis (IPF) was diagnosed. The PaO2 of blood could be maintained between 50 mm Hg and 70 mm Hg with a high dose pulse corticosteroid therapy, although this dose could not be reduced. Azathioprine in addition to prednisolone provoked deterioration. Twelve weeks after admission, cyclosporin A (Cs A), a known immunosuppressant, was started together with prednisolone. The PaO2 reverted to normal within 1 month and prednisolone could be tapered off within 6 months. Two years after admission, the patient is free of symptoms on continuous Cs A therapy. This case seems to be the first case successfully treated with Cs A.

• Authors: M Fukazawa, M Kawano, S Hisano, K Ueda, K Matsuba
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 149 Issue 6 Pg. 441-2 (Mar 1990) ISSN: 0340-6199 [Print] Germany
• PMID: 2332017 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cyclosporins
• Prednisolone
• Azathioprine

Topics

• Administration, Oral
• Azathioprine (pharmacology)
• Child
• Cyclosporins (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Prednisolone (adverse effects, therapeutic use)
• Pulmonary Fibrosis (drug therapy)
• T-Lymphocytes (drug effects)