Abstract | OBJECTIVE: METHOD: A total of 67 RA patients [mean age 56 ± 12 years, median disease duration 8 (3-15) years] were assessed. Routine biochemistry tests, lipid profile, glycaemic profile [ glucose, insulin, homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI)], and inflammatory markers were measured in all patients. ADMA levels were measured by enzyme-linked immunosorbent assay (ELISA). Regression analyses were performed to identify predictors of ADMA in RA. RESULTS: Regression analysis revealed that HOMA (β = 0.149, p = 0.003) was an independent predictor of ADMA in RA. From the drug factors, anti-hypertensive medication use was associated with lower ADMA levels (β = -0.081, p = 0.004). ADMA was not associated with RA disease-related parameters or any of the other cardiovascular risk factors that were assessed. CONCLUSIONS: HOMA, a strong indicator of insulin resistance, seems to be the main predictor of elevated ADMA levels in RA patients; ADMA may reflect an important pathway linking abnormal insulin metabolism with endothelial dysfunction in RA.
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Authors | T Dimitroulas, A Sandoo, J J J C S Veldhuijzen van Zanten, J P Smith, J Hodson, G S Metsios, A Stavropoulos-Kalinoglou, G D Kitas |
Journal | Scandinavian journal of rheumatology
(Scand J Rheumatol)
Vol. 42
Issue 3
Pg. 176-81
( 2013)
ISSN: 1502-7732 [Electronic] England |
PMID | 23311682
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- N,N-dimethylarginine
- Arginine
|
Topics |
- Adult
- Aged
- Arginine
(analogs & derivatives, blood)
- Arthritis, Rheumatoid
(blood)
- Female
- Homeostasis
- Humans
- Insulin Resistance
- Male
- Middle Aged
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