A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.

Abstract

BACKGROUND:

Personality correlates highly with both cocaine and nicotine dependencies (CD, ND), and their co-morbid psychopathologies. However, little is known about the nature of these relationships. This study examined if environment (marriage) or genetics (a single SNP, CHRNA5*rs16969968) would moderate the correlation of personality with CD, ND and cocaine-induced paranoia (CIP) in African and European Americans (AAs, EAs).

METHODS:

1432 EAs and 1513 AAs were examined using logistic regression. Personality was assessed by NEO-PI-R, while CD, ND and CIP were diagnosed according to DSM-IV. ND and CD were examined as binary traits and for the analysis of CIP, subjects were divided into 3 groups: (A) Controls with no CIP; (B) CD cases without CIP; and (C) CD cases with CIP. Multiple testing was Bonferroni-corrected.

RESULTS:

For CD and ND in the EA population, marital status proved to be a significant moderator in their relationship with openness only (OR = 1.90, 95%CI = 1.36-2.64, p = 1.54e-04 and OR = 2.12, 95%CI = 1.52-2.90, p = 4.65e-06 respectively). For CIP, marriage was observed to moderate its correlation with openness and neuroticism (OR = 1.39, 95%CI = 1.18-1.63, p = 7.64e-04 and OR = 1.26, 95%CI = 1.12-1.42, p = 1.27e-03 respectively). The correlations moderated by rs16969968 were those of conscientiousness and CD (OR = 1.62, 95%CI: 1.23-2.12, p = 8.94e-04) as well as CIP (OR = 1.21, 95%CI: 1.11-1.32, p = 4.93e-04 when comparing group A versus group C). No significant interactions were observed in AA population. The Bonferroni-corrected significance threshold was set to be 1.67e-03.

CONCLUSION:

The role of personality in CD and CIP may be interceded by both environment and genetics, while in ND by environment only.

• Authors: Tetyana Zayats, Bao-Zhu Yang, Pingxing Xie, James Poling, Lindsay A Farrer, Joel Gelernter
• Journal: PloS one (PLoS One) Vol. 8 Issue 1 Pg. e49368 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 23308091 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• CHRNA5 protein, human
• Dopamine Uptake Inhibitors
• Nerve Tissue Proteins
• Receptors, Nicotinic
• Cocaine

Topics

• Adult
• Black or African American (genetics)
• Cocaine
• Cocaine-Related Disorders (complications, diagnosis, epidemiology, genetics, psychology)
• Dopamine Uptake Inhibitors
• Female
• Humans
• Male
• Marital Status
• Middle Aged
• Nerve Tissue Proteins (genetics)
• Paranoid Disorders (chemically induced, diagnosis, epidemiology, genetics)
• Personality
• Polymorphism, Single Nucleotide
• Receptors, Nicotinic (genetics)
• Risk Factors
• Tobacco Use Disorder (diagnosis, epidemiology, genetics)
• White People (genetics)