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[A case of effective chemoradiotherapy using docetaxel and nedaplatin for recurrent anal canal squamous cell carcinoma].

Abstract
69-year-old woman underwent resection of a tumor diagnosed as squamous cell carcinoma of the anal canal. After 4 years and 5 months, computed tomography(CT)showed abdominal and pelvic lymph node swelling. Chemotherapy consisting of biweekly docetaxel(35mg/m2)+nedaplatin(35mg/m2)achieved a partial response. After 20 cycles of chemotherapy, the patient was treated with radiotherapy because of a pelvic lymph node recurrence. Since then, no recurrence has occurred for 16 months. The adverse event was Grade 2 in leucopenia and neutropenia. This case suggested that chemoradiotherapy consisting of docetaxel +nedaplatin may be effective and safe for treating anal canal squamous cell carcinoma.
AuthorsHijiri Takeuchi, Shiro Hori, Takahisa Fujita, Seiji Mori, Shunju Indo, Takashi Maeba
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 1 Pg. 115-7 (Jan 2013) ISSN: 0385-0684 [Print] Japan
PMID23306932 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Organoplatinum Compounds
  • Taxoids
  • Docetaxel
  • nedaplatin
Topics
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Anus Neoplasms (therapy)
  • Carcinoma, Squamous Cell (therapy)
  • Chemoradiotherapy
  • Docetaxel
  • Female
  • Humans
  • Organoplatinum Compounds (administration & dosage)
  • Recurrence
  • Taxoids (administration & dosage)

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